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Generic vs brand adderall ir idic individual) in the context of current literature on the pharmacokinetics of amphetamine, methylphenidate, and cocaine. Analyses were carried out using a combination of the MIXED procedure and trapezoidal method the maximum-likelihood method. analysis of variance with Bonferroni post hoc tests was used to evaluate significant differences between the 3 drug conditions. Results During the 12 weeks of study, participants consumed a mean of 20.2±4.8 mL/day/kg body weight dextroamphetamine, 683.1±161.7 mg/day/kg of methylphenidate, and 20.8±7.1 ml/day/kg body weight of cocaine respectively (mean±SD, p<0.001 compared with placebo). There were no significant differences at any time point as regards the concentration in any of 3 drug conditions (F(2,36)=0.07, p=0.84, η2=0%). Discussion In our study, we evaluated the acute pharmacokinetics of dextroamphetamine, methylphenidate, and cocaine in healthy volunteers. The results are presented in Table 1. The dextroamphetamine dose of 3 drugs is significantly lower than the maximum daily dosage of cocaine. The concentration dextroamphetamine in plasma was significantly higher than methylphenidate and the concentration of cocaine in plasma was significantly higher than cocaine. The Pharmacy assistant online training in canada dextroamphetamine plasma concentration is probably caused by the more rapid elimination of dextroamphetamine during the administration cocaine. On other hand, dextroamphetamine is not eliminated as rapidly the other 2 drugs. This is presumably due to its high affinity for and sensitivity the N-methyl-D-aspartate (NMDA) receptor, especially at lower doses (Figs 2 and 3 ). It is also worth noting Amlodipine cost uk that dextroamphetamine and the others have same affinity, but opposite potency for the 5-HT 2A receptor (Figs 6 and 7 ). Although dextroamphetamine has a higher affinity for the 5-HT 1A receptor than other 3 drugs, it is only weakly active for the 5-HT 2C receptor. Dextroamphetamine has high affinity for the NMDA receptor compared with other drugs, especially the cocaine. Dextroamphetamine is weakly active for the 5-HT 2C receptor, but more active than either avodart vs flomax vs proscar methamphetamine or methylphenidate at the 5-HT 2C receptor (Figs 6 and 7 ). All avodart vs dutasteride drugs showed similar pharmacodynamic (Figs 2 and 3 ) but different pharmacokinetic (Figs 6 and 7 ) profiles. There is a high degree of overlap across the pharmacodynamic parameters for all drugs tested at each time point (Fig. 2 and 3 ). Therefore, the pharmacodynamic profiles are only presented briefly to summarize their differences compared with control. Overall, at least for the dextroamphetamine dose of 3 drugs, the acute pharmacokinetics of dextroamphetamine were similar and comparable with those of methamphetamine and methylphenidate. Furthermore, all drugs had similar pharmacokinetic profiles when compared with the placebo. differences in pharmacokinetic profiles between dextroamphetamine, methylphenidate, and cocaine were of no importance and pharmacokinetic effects can be attributed to these differences. Although dextroamphetamine is absorbed from the gastrointestinal tract more quickly than any other drug tested, the mean plasma volume of dextroamphetamine was greater than that of methylphenidate, indicating less rapid elimination of dextroamphetamine after consumption than for other amphetamines. At lower doses, the pharmacokinetic profiles for all drugs were similar. The pharmacokinetics of cocaine were similar to those of the other 3 drugs and were not different from the placebo. differences in pharmacokinetics of dextroamphetamine, methamphetamine, and methylphenidate were not likely a consequence of any these drug differences and could in theory have been caused by other factors. We therefore cannot conclude that the dextroamphetamine, methylphenidate, and cocaine profiles are due to differences in their metabolism or to differences in the absorption, metabolism, and clearance patterns for the different drugs. Conclusion The acute pharmacokinetics of dextroamphetamine, amphetamine, and cocaine are essentially similar to those reported in the literature. pharmacodynamic profiles of drugs are in general very similar, with few exceptions. The pharmacokinetics of dextroamphetamine, methylphenidate, and cocaine are not likely related to differences in their metabolism or clearance.
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